Active Biotech och Ipsen meddelar att utvecklingen av tasquinimod

Active Biotech Årsredovisning 2014 - myPaper.se

laquinimod utvecklar Active Biotech tillsammans med franska Ipsen en läkemedelskandidat mot prostatacancer, tasquinimod, i fas III. Tasquinimod klassas av Klas Palin som en starkare läkemedelskandidat då den utvärderats på en relativt stor patientbas, 1 200 patienter bara i fas III-studien. Background: Tasquinimod is a small molecule with immunomodulatory, anti-angiogenic, and anti-metastatic properties that targets the tumor microenvironment. This study aimed to obtain a clinical proof of concept that tasquinimod was active and tolerable in patients with advanced solid tumors. Study Of Tasquinimod In Asian Chemo-Naïve Patients With Metastatic Castrate-Resistant Prostate Cancer (TasQ003) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. 2012-06-04 · LUND, Sweden & PARIS --(Business Wire)-- Regulatory News: Active Biotech (NASDAQ OMX NORDIC: ACTI) and Ipsen (Euronext: IPN; ADR: IPSEY) today presented overall survival (OS) data from the tasquinimod Phase II study in chemotherapy-naïve metastatic castrate resistant prostate cancer (CRPC) at the scientific conference "2012 ASCO Annual Meeting" held in Chicago (USA). 2014. Ipsen meddelade under 2012 att man inlett ytterligare kliniska studier med tasquinimod, dels som underhållsterapi, dels i fyra andra cancerformer.

BACKGROUND: Tasquinimod (ABR-215050) is an orally active quinoline-3-carboxamide analog that inhibits occurrence of experimental metastasis and delays disease progression of castration resistant prostate cancer in humans. Ipsen strengthens its business in urology-oncology with the acquisition of the rights to HEAVY ® (a drug aimed at improving bladder cancer detection) and the establishment of two significant partnerships with: Active Biotech for the co-comelopment and commercialization of tasquinimod (a molecule for the treatment of metastatic and castration-resistant prostate cancers), and Institut Gustave Ipsen and Active Biotech today announced the initiation of a new phase II proof of concept clinical trial, evaluating the activity of tasquinimod in advanced metastatic castrate resistant prostate Ipsen (Euronext: IPN; ADR: IPSEY) har idag på den vetenskapliga konferensen “2012 ASCO Annual Meeting” som hålls i Chicago (USA) presenterat överlevnadsdata (OS) från tasquinimod Överlevnadsdata från fas II presenterade på 2012 ASCO Annual Meeting Lund och Paris (Frankrike) den 4 juni 2012, Active Biotech (NASDAQ OMX NORDIC: ACTI) och Ipsen (Euronext: IPN; ADR: IPSEY Active Biotech receives tasquinimod milestone payment from Ipsen. This announcement is distributed by Thomson Reuters on behalf of Thomson Reuters clients. The owner of this announcement warrants Avtalet ger Ipsen exklusiva rättigheter till kommersialisering av tasquinimod globalt, förutom i Nord- och Sydamerika och Japan där Active Biotech behållit alla kommersialiserings- och Tasquinimod’s unique mode of action potentially attractive in multiple malignant tumors. Regulatory News: Ipsen (Paris:IPN) (Euronext: IPN; ADR: IPSEY) today announced that it will shortly Regulatory News: Active Biotech's and Ipsen's castrate resistant prostate cancer project, TASQ, will be presented at the 27th Annual EAU Congress held in | April 7, 2021 Ipsen Group to help develop, market tasquinimod for mCRPC Posted on April 18, 2011 by Sitemaster Apparently, over the weekend, Active Biotech completed a deal with the Ipsen Group whereby Ipsen will have responsibilities for the development and marketing of tasquinimod everywhere in the world except North and South America and Japan, … <0> Ipsen initiates a phase II “Switch maintenance” trial in metastatic castrate-resistant prostate cancer with tasquinimod RegulatoryNews: Tasquinimod biomarkörsdata från fas II presenterade på ESMO 2012 Lund och Paris (Frankrike) den 1 oktober, 2012. Active Biotech (NASDAQ OMX NORDIC: ACTI) och Ipsen (Euronext: IPN; ADR: IPSEY) har på den vetenskapliga konferensen ESMO (European Society for Medical Oncology) som hålls i Wien den 28 september-2 oktober, och Ipsen (Euronext: IPN; ADR: IPSEY) meddelar idag att den globala, registreringsgrundande, randomiserade, dubbelblinda, placebokontrollerade fas III-studien av tasquinimod i patienter med Background Tasquinimod (a quinoline-3-carboxyamide) is a small molecule immunotherapy with demonstrated effects on the tumor microenvironment (TME) involving immunomodulation, anti-angiogenesis and inhibition of metastasis. A target molecule of tasquinimod is the inflammatory protein S100A9 which has been shown to affect the accumulation and function of suppressive myeloid cell subsets in Active Biotech and Ipsen have taken the decision to discontinue the development of tasquinimod in prostate cancer.

Randomized, double-blind, placebo-controlled phase III study

2013 — Active Biotech och Ipsen uppdaterar analysplanen för studien 10TASQ10 vilken utvärderar tasquinimod för behandling av prostatacancer. Lund, Sverige and Paris, Frankrike, den 16 april, 2015 - Active Biotech (NASDAQ STOCKHOLM: ACTI) och Ipsen (Euronext: IPN; ADR: IPSEY) presenterar idag 13 dec. 2020 · 1 MB — Following a successful Phase II trial, French.

Active Biotech MLI om TASQ och Ipsen Forum Placera - Avanza

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Studierna April 15, 2015 Active Biotech and Ipsen announce their decision to discontinue the development of tasquinimod in prostate cancer This article or press release has no online content.

Active Biotech (NASDAQ OMX NORDIC: ACTI) och Ipsen (Euronext: IPN; ADR: IPSEY) meddelar idag Milestone Payment of 12 Million Euros under the Terms of the Agreement Regulatory News: Active Biotech (NASDAQ OMX NORDIC: ACTI) and Ipsen (Euronext: IPN; ADR: IPSEY) (Paris:IPN) today Active Biotech och samarbetspartnern Ipsen meddelade på morgonen negativa studieresultat från en klinisk studie med läkemedelskandidaten tasquinimod.
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2015 — Efter nya studiedata avbryter Active Biotech och Ipsen alla studier av tasquinimod som behandling av prostatacancer. 6 aug.

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Tasquinimod treatment also affected expression of factors involved in the pre‐metastatic niche in the bone microenvironment (Lox , Cdh2 , Cdh11 , and Cxcl12 ). In addition, tasquinimod treatment caused a decreased osteogenic response indicated by decreased expression of Ocn , Runx2 , and Col1a2 and increased expression of osteoclast stimulating CSF2. Lund and Paris , 16 April 2015 - Active Biotech and Ipsen today announced top line results of the 10TASQ10 study. While the study showed that tasquinimod reduced the risk of radiographic | March 30, 2021 Avtalsenlig delmålsbetalning om 12 miljoner EUR Lund, Sverige och Paris, Frankrike den 9 oktober 2013.

Active Biotech avbryter studier av tasquinimod - Dagens Industri

October 09, 2013 at 01:36 AM EDT. LUND, Sweden and PARIS, Oct. 9, 2013 (GLOBE NEWSWIRE) -- Active Biotech (NASDAQ OMX NORDIC: ACTI) and Ipsen 2013-10-09 PARIS, France—Active Biotech AB and Ipsen have entered intoa broad partnership to co-develop and commercialize Active Biotech'sinvestigational compound Tasquinimod (TASQ). A global Phase III trial of TASQin men with metastatic castrate-resistant prostate cancer (CRPC) was recentlyinitiated by Active Biotech, and patient recruitment has begun. Lund and Paris , 16 April 2015 - Active Biotech and Ipsen today announced top line results of the 10TASQ10 study. While the study showed that tasquinimod reduced the … Milestone Payment of 12 Million Euros under the Terms of the Agreement Regulatory News: Active Biotech (NASDAQ OMX NORDIC: ACTI) and Ipsen (Euronext: IPN; ADR: IPSEY) (Paris:IPN) today Ipsen and Active Biotech partnered in 2011 to co-develop and commercialize tasquinimod..SSE:ACTI), Lund, Sweden Ipsen Group (Euronext:IPN; Pink:IPSEY), Boulogne-Billancourt, France Product: Tasquinimod ( TASQ) ( ABR-215050..1 mg oral tasquinimod did not improve OS vs. placebo (HR=1.09, 95% CI: 0.94, 1.28).

<0> Ipsen initiates a phase II “Switch maintenance” trial in metastatic castrate-resistant prostate cancer with tasquinimod RegulatoryNews: 2012-10-03 In 2011, Active Biotech and Ipsen entered into a broad partnership for the co-development and commercialization of tasquinimod. Under the terms of the agreement, Active Biotech has granted Ipsen exclusive rights to commercialize tasquinimod worldwide, except for North and South America and Japan, where Active Biotech has retained all commercial and marketing rights. Regulatory News: Active Biotech's and Ipsen's castrate resistant prostate cancer project, TASQ, will be presented at the 27th Annual EAU Congress held in | April 7, 2021 2015-04-16 Active Biotech receives tasquinimod milestone payment from Ipsen. This announcement is distributed by Thomson Reuters on behalf of Thomson Reuters clients. The owner of this announcement warrants Study Of Tasquinimod In Asian Chemo-Naïve Patients With Metastatic Castrate-Resistant Prostate Cancer (TasQ003) Ipsen: More Information. Go to Top of Page Study Description Study Design Arms and Interventions Outcome Measures Eligibility Criteria Contacts and Locations More Information.